Elleste Duet - Drug info, indications, side effects, dosage, FAQ

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Usage of Elleste Duet

Indications: Treatment of menopausal symptoms such as night sweats and hot flushes in women at least one year past the menopause who have an intact uterus. Treatment of the postmenopausal sequelae of oestrogen withdrawal, including atrophic vaginitis and atrophic urethritis. Prophylaxis of postmenopausal osteoporosis in women at risk of developing fractures
Contra Indications: Known or suspected pregnancy. Known, suspected, or past history of breast cancer. Known or suspected oestrogen-dependent neoplasia. Vaginal bleeding of unknown aetiology. Active deep vein thrombosis, thromboembolic disorders, or a history of confirmed venous thromboembolism. Acute or chronic liver disease or history of liver disease where the liver function tests have failed to return to normal. Rotor's syndrome or Dubin-Johnson syndrome. Severe cardiac or renal disease. Hypersensitivity to one or more of the ingredients. Pregnancy and lactation

Drug description Elleste Duet

Drug description: Elleste Duet 1 mg: (16 white f-c tablets marked 01); estradiol 1 mg, norethisterone acetate 1 mg (12 green f-c tablets marked P1). Elleste Duet 2 mg: (16 orange f-c tablets marked 02); estradiol 2 mg, norethisterone acetate 1 mg (12 grey f-c tablets marked P2)
Generic name: Estradiol [oestradiol]
Drug class description: Oestrogens / progestogens
Drug description: Round, grey, biconvex, film- coated tablets embossed with 'P2' on one side
Generic name: Estradiol [oestradiol], norethisterone acetate
Drug class description: Oestrogens / progestogens

Special precautions Elleste Duet

History or increased risk of thromboembolic disorders. Mild liver function every 8 to 12 weeks. Closely monitor patients with cholelithiasis, otosclerosis, migraine, multiple sclerosis, epilepsy, diabetes, hypertension, porphyria, uterine fibroids, tetany. Examine blood pressure, pelvic organs and breasts (particularly those with fibrocystic disease of the breast or a family history of breast cancer) before and regularly during treatment. If breakthrough bleeding is persistent, perform endometrial assessment, which may include biopsy

Adverse and side effects Elleste Duet

GI upset, nausea, vomiting, weight gain, breast tenderness and enlargement, breakthrough bleeding, headache, dizziness, impaired liver function, cholestatic jaundice, epistaxis, migraine, thromboembolic disorders, exacerbation of varicose veins, increased blood pressure, transient erythema, generalised pruritus. REASONS FOR IMMEDIATE DISCONTINUATION OF TREATMENT: Occurence of migraine-type headaches for the first time, frequent severe headaches, acute visual disturbances, signs of thrombophlebitis or thromboembolism, or any other possible prodromal symptoms of vascular occlusion. Rise in blood pressure. Jaundice. Pregnancy. Discontinue six weeks before major elective surgery and during immobilisation entailing risk of thrombosis

Presentation Elleste Duet

  • Elleste Duet Duet Conti
  • Elleste Duet Tablets, estradiol 2mg, norethisterone acetate 1mg
  • Elleste Duet Elleste Duet 1 mg : Estradiol 1 mg . Elleste Duet 2 mg : Estradiol 2 mg

Do you have a question about Elleste Duet?

Our experts have answered 9 questions about Elleste Duet.

you probably had a withdraw bleeding which is normal after you stopped your hormone replacement therapy. It should settle. If you however continue to bleed then please see your doctor to arrange investigations of the lining of your womb

Elleste Conti is designed as 'no bleed' preparation for women who are more than 12 months following their last natural mestrual period, so there are no breaks (either without tablets, or with placebo tablets) in the HRT pack and the same dose of hormone is administered throughout the month. Elleste Duet has two different strengthst of hormone at different times of the month and a monthly bleed is the norm. This type of HRTshould be taken for the first year or so after the last natural menstrual period.

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Dr. David Charles Hunter



It is quite normal to have some sort of breakthrough bleeding in the first six months of HRT. The likelihood is that the bleeding will settle on its own but you need to continue taking the tablets. If the bleeding does not settle it would be sensible to contact your gp in first instance.

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Dr. Joseph Aquilina

Gynaecologist, Obstetrician


Hello. If your GP has prescribed a particular formulation of hrt then it would be best to go back onto the original type. The main reason is that in women in your age group irregular bleeding is more common with the continuous hrt. Hope this helps

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Mr. Philip David Kaloo Premium Profile Has a more complete profile



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