Information about Botulinum toxin therapy
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Botox is a trade name of botulinum toxin which is the most potent neurotoxin. Because of it's dilution however it can be safely used to cause localised paralysis of specific muscles and glands. Examples include cosmetic indications (e.g. forehead muscles causing wrinkles), excessive sweating in armpits or hands, overactive bladder, spasticity. Side effects include bruising, pain, over-correction, undercorrection, allergic reactions
Botox can be used to treat bladder overactivity and bladder pain syndrome that has not responded to other medical treatments. Treatment involves using a telescope to look into the bladder and inject into the inner layer of the bladder wall at about 20-30 sites. This can be done in outpatient or theatre. It may have to be repeated when the effectiveness wears off. Possible risk is retention of urine requiring intermittent catheter use temporarily.
Botox or botulinum toxin is the most potent nerve agent and produced by a bacterium called clostridium botulinum. This toxin can be produced commercially and diluted. Since this preparation does not contain the bacterium, no excess toxin can be produced. In commercially available concentrations this agent is relatively safe. For cosmetic reasons about 50 units are injected under or into the skin. The lethal dose is about 3000 units.
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